Expert GPCR Cellular Assays (GN) - #2078092

ABOUT US

Proteros is a privately held early-stage services provider in structure-based drug discovery with a cutting-edge discovery engine tailored to unlock even the most technically challenging targets. Proteros’ work is built on scientific excellence and supports its clients to reach the right results and accelerate their overall research timelines. Proteros supports most of the world’s 20 largest pharma companies and more than 250 pharmaceutical and biotech partners in the US, Europe and Japan.

YOUR MISSION

• Contribute to multidisciplinary and challenging research projects in the field of drug discovery.
• Provide expert knowledge in GPCR biology, focusing on GPCR/G-protein interactions and ligand pharmacology.
• Independently design, execute, and interpret cellular functional assays for profiling and classifying ligands based on their mode of stimulation.
• Develop and apply fluorescence and luminescence assays with continuous kinetic readout on FLIPR or FDSS workstations.
• Perform ligand screening in HTS mode and ligand profiling experiments.
• Utilize cell culture techniques and select relevant cell lines.
• Ensure compliance with industry standards for screening, profiling, and characterization of ligand–GPCR binding.
• Maintain thorough documentation of work according to internal guidelines and customer requirements using a laboratory management system (LIMS).

YOUR PROFILE

• Ph.D. in cell biology, pharmacology, biochemistry, or a related field, with a strong focus on membrane protein signaling.
• At least 3 years of experience in a drug discovery environment, covering the process from screening to lead identification.
• Deep understanding of GPCR pharmacology and G-protein interactions.
• Hands-on experience with FLIPR or FDSS workstations
• Proven expertise in other fluorescence- and luminescence-based GPCR assay technologies, such as TR-FRET, FRET, nanoBRET.
• Strong analytical and problem-solving skills with a high level of accuracy and attention to detail.
• Ability to work independently and in interdisciplinary teams across different projects.

WHY US?

• An innovative professional field in an exciting industry
• An inspiring working atmosphere as fertile ground for your further development
• A comprehensive induction that prepares you optimally for your area of responsibility
• Multicultural teams and an open corporate culture
• A salary in line with the market